Chinese instructions for Mobocertinib

Indications:

1.Mobocertinib (Mobocertinib) is an oral drug used to treat EGFR gene mutation-positive advanced or metastatic non-small cell lung cancer (NSCLC).

2.It is suitable for patients who have experienced disease progression after EGFR TKI treatment, especially those carrying the T790M mutation.

Mechanism of action:

1.Mobosetinib belongs to the tyrosine kinase inhibitor (TKI) class of drugs, which prevents the growth and division of cancer cells by inhibiting the activity of EGFR mutants.

2.Unlike traditional EGFR TKIs, mobosetinib also has a highly inhibitory effect on EGFR T790M mutations, and therefore has a unique efficacy in drug-resistant NSCLC patients.

Pharmacology:

1.Mobosetinib is rapidly absorbed in the body, reaching peak concentration usually within 2 hours.

2.It is mainly metabolized by the liver, in which CYP3Aenzyme is the main pathway of its metabolism.

3.The excretion of drugs is mainly through feces, and metabolites are mainly excreted in the form of urine.

Dosage and usage:

1.Adult patients are usually recommended to take it orally once daily at a dose of 160mg.

2.The medication can be taken with or without food, but should be avoided with high-fat foods to reduce the risk of side effects.

3.Dosage adjustments may be required based on the patient's liver function or drug interactions.

Side effects:

Common side effects include diarrhea, rash, fatigue, nausea, vomiting, loss of appetite, headache, etc.

Severe side effects may include liver function abnormalities, interstitial pneumonia, electrocardiogram QT interval prolongation, etc. Patients should have regular monitoring of liver function and electrocardiogram.

Warnings and Precautions:

1.Patients should tell their doctors about their history of drug allergies and any potential heart problems.

2.Mobosetinib may cause serious skin reactions such asStevens-Johnson syndrome. Patients should inform their doctor immediately of any skin abnormalities.

3.Patients taking moboxetinib should regularly monitor blood routine, liver function, electrocardiogram, etc.

Contraindications:

This medication should not be used by patients who are allergic to mobosertinib or any of its ingredients.

Drug interactions:

Mobosetinib may interact withCYP3A4Drug interactions occur with inducers and inhibitors, so patients should inform their doctors of all medications they are currently taking.

Drug use for special groups:

1.In patients with impaired hepatic function, the dose of mobosertinib may need to be adjusted.

2.The safety of mobosetinib in pregnant and lactating women has not been determined, so pregnant and lactating women should avoid using this drug or use it under the advice of a doctor.

Listing and price status:

Mobotinib is currently on the market in China, but it is not included in medical insurance. Patients need to pay for it in full, so the price is very high. Please consult the local hospital pharmacy for specific prices. Other versions include the Hong Kong version of the original drug Mobotinib, which costs around 7,000 to 8,000 yuan. The generic drug of Mobotinib is mainly a Laotian generic drug. The price is about three to four thousand yuan, which is nearly half cheaper than the original drug. The ingredients of the original drug and the generic drug are the same.