What medicine is Niraparib?

Niraparib (Niraparib) is a PARP inhibitor approved for the maintenance treatment of adults with advanced ovarian cancer who have a complete or partial response to platinum-based chemotherapy. In a placebo-controlled Phase III trial of patients with newly diagnosed advanced ovarian cancer, niraparib significantly prolonged progression-free survival in two predetermined populations: those with altered homologous recombination DNA repair pathways [i.e., homologous recombination deficiency positive (HRd)] and the entire trial population.

Prespecified exploratory subgroup analysis showed that niraparib was also effective in patients with homologous recombination deficiency-negative or homologous recombination proficient(HRp). Niraparib has a manageable tolerability profile and myelosuppression is a major safety concern. Manage hematologic responses with monitoring and dose reduction or interruption. An individualized dosing regimen based on body weight and platelet count introduced during the trial (and subsequently approved) appeared to improve hematologic tolerability. Niraparib is a useful first-line maintenance treatment option for adult patients with advanced ovarian cancer who respond to platinum-based chemotherapy, regardless of homologous recombination deficiency status, and is also a promising option for patients with HRp who have limited maintenance treatment options.

NiraparibThe original drug has been launched in China and is included in medical insurance, but reimbursement is limited to eligible patients. The price of a common specification100mg*30 capsules per box may be more than 5,000 yuan. The original niraparib drug marketed overseas is more expensive than domestically. There are also generic niraparib drugs produced in other countries. Their pharmaceutical ingredients are basically the same as those of the original niraparib drug sold domestically and abroad. The price of 100mg*30 tablets per box produced by a Bangladesh pharmaceutical factory may be more than 1,000 yuan (the price may fluctuate due to exchange rates).