Is it okay to take 1 tablet of Niraparib for a long time?

After single dose administrationAfter 300 mg niraparib, the mean (SD) peak plasma concentration (Cmax) was 804 (403) ng/mL. The niraparib exposure (Cmax and AUC) increased in a dose-proportional manner as the daily dose was increased from 30 mg (0.1 times the approved recommended dose) to 400 mg (1.3 times the approved recommended dose). For the 30-400 mg dose range, the cumulative rate of niraparib exposure was approximately 2-fold after 21 days of repeated daily dosing.

Niraparib is available in hard capsules (100 mg). When treating advanced advanced breast cancer, 3 capsules are taken together at approximately the same time each day for a total daily dose of 300 mg niraparib. Taking the capsules before bed can help avoid nausea. If side effects are too severe, treatment may be stopped for a period of time or the dose may be adjusted. If the cancer continues to progress despite treatment, treatment is stopped. If the patient takes one niraparib pill for a long time, the efficacy may be reduced or the therapeutic purpose cannot be achieved. However, if the patient cannot tolerate the 300 mg dose, the drug dose needs to be adjusted to one pill under the guidance of a doctor.

NiraparibThe original drug has been launched in China and is included in medical insurance, but reimbursement is limited to eligible patients. The price of a common specification100mg*30 capsules per box may be more than 5,000 yuan. The original niraparib drug marketed overseas is more expensive than domestically. There are also generic niraparib drugs produced in other countries. Their pharmaceutical ingredients are basically the same as those of the original niraparib drug sold domestically and abroad. The price of 100mg*30 tablets per box produced by a Bangladesh pharmaceutical factory may be more than 1,000 yuan (the price may fluctuate due to exchange rates).