Should I take niraparib after chemotherapy for ovarian cancer?

Currently, most women are diagnosed when their cancer has spread, making treatment more difficult and recurrence more likely. Niraparib (Niraparib) can be used to treat late recurrence. It inhibits the activity of various proteins that enable cancer to grow, and it is used to treat a type of advanced ovarian cancer called high-grade serous epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer in women. This is an option for patients with late relapse and who have responded to platinum-based chemotherapy ("platinum-sensitive relapse").

Ovarian cancer is caused by genetic changes (mutation) in cells. Ovarian cancer often goes undetected for a long time because there are initially no or only non-specific symptoms. By the time a tumor is discovered, it is usually in an advanced stage. Surgical removal of advanced ovarian cancer. This is usually followed by platinum-based chemotherapy. Maintenance therapy can be given after the cancer responds (completely or partially) to platinum-based chemotherapy and may provide more time without the chance of the cancer returning. Maintenance therapy allows patients to continue to take an active role in their cancer treatment. In the single-arm QUADRA trial, the objective response rate (ORR) was 24% and the estimated median duration of response (DOR) was 8.3 months. For patients with tBRCAm ovarian cancer, the ORR was 39%.

NiraparibThe original drug has been launched in China and is included in medical insurance, but reimbursement is limited to eligible patients. The price of a common specification100mg*30 capsules per box may be more than 5,000 yuan. The original niraparib drug marketed overseas is more expensive than domestically. There are also generic niraparib drugs produced in other countries. Their pharmaceutical ingredients are basically the same as those of the original niraparib drug sold domestically and abroad. The price of 100mg*30 tablets per box produced by a Bangladesh pharmaceutical factory may be more than 1,000 yuan (the price may fluctuate due to exchange rates).