How much does a box of Zanubrutinib capsules cost in 2023?

Zanubrutinib (Zanubrutinib) is a next-generation irreversible BTK inhibitor developed by BeiGene in 2012. It is used to treat B-cell malignant tumors. It has good activity and high specificity for BTK. It has been shown to be effective against several non-Hodgkin lymphomas, including mantle cell lymphoma (MCL), Waldenström's macroglobulinemia (WM), marginal zone lymphoma (MZL), chronic lymphocytic leukemia (CLL), or small lymphocytic lymphoma (SLL), both as monotherapy and in combination with other targeted, non-chemotherapeutic agents.

Zanubrutinib is intended for combination therapy, either as a lead drug with traditional cytotoxic drugs or as an add-on therapy with a bcl-2 inhibitor, monoclonal antibody, biclonal antibody or immunotoxin. In addition, zanubrutinib may enhance the efficacy of CAR-T cells in treating lymphoma,This approach enablesMRD-guided limited treatment duration and may prevent the development of drug resistance. On the other hand, such an effective regimen carries the risk of adverse events that may be tolerated and controlled only in healthy patients. Adverse reactions of ≥30% were decreased neutrophil count, decreased platelet count, upper respiratory tract infection, bleeding, and musculoskeletal pain.

The original drug of zanubrutinib has been launched in China and has been included in the medical insurance. The price of 80mg*64 capsules per box may be around 6,000 yuan. The original drug of zanubrutinib marketed overseas is relatively expensive. There are currently no generic drugs of zanubrutinib on the market.