How to take Vandetanib

Vandetanib (Vandetanib) is available in 300 mg and 100 mg tablets. The recommended daily dose of oral vandetanib is 300 mg once daily. Vandetanib can be taken with or without food. If a patient misses a dose and it is less than 12 hours before the next dose, the missed dose should not be taken.

Patients who have difficulty swallowing vandetanib capsules whole should not crush the capsules. The tablets may be dispersed in a glass containing 2 ounces of noncarbonated water and stirred for approximately 10 minutes until the tablets are dissolved; the mixture should be swallowed immediately. Vandetanib may also be administered via a nasogastric or gastrostomy tube. For patients who experience adverse reactions of Grade 3 or higher toxicity after taking it, reduce the daily dose of vandetanib from 300 mg to 200 mg, and then to 100 mg; for patients with moderate (creatinine clearance ≥30 to <50 mL/min) renal impairment, the starting dose is reduced to 200 mg; it is not recommended for patients with moderate and severe hepatic impairment. Due to metabolism by CYP3A4, concomitant use of strong inducers and inhibitors of CYP3A4 should be avoided, as should drugs known to prolong the QT interval.

The original drug vandetanib has not yet been marketed in China, so it is not included in medical insurance. The original drug specifications of vandetanib listed overseasThe price of each box of 300mg*30 tablets may be more than 30,000 yuan (the price may fluctuate due to the exchange rate). There is currently no generic drug of vandetanib produced and launched. For more drug information and specific prices, please consult the medical consultant of Yaode.