What are the side effects of Venetoclax?

Venetoclax (Venetoclax) is used to treat chronic lymphocytic leukemia or small lymphocytic leukemia in adults. Also used in combination with other medicines to treat adults 75 years of age or older who have acute myeloid leukemia or who are unable to use standard chemotherapy due to other medical conditions.

In clinical studies in chronic lymphocytic leukemia/small lymphocytic lymphoma, including monotherapy or combination therapy, the most common adverse reactions (≥20%) with venetoclax were neutropenia, thrombocytopenia, anemia, diarrhea, nausea, upper respiratory tract infection, cough, musculoskeletal pain, fatigue, and edema. In clinical studies in acute myeloid leukemia, including combination therapy, the most common adverse reactions (≥30%) were nausea, diarrhea, thrombocytopenia, constipation, neutropenia, febrile neutropenia, fatigue, vomiting, edema, pyrexia, pneumonia, dyspnea, bleeding, anemia, rash, abdominal pain, sepsis, musculoskeletal pain, dizziness, oropharyngeal pain, and hypotension.

The original drug of Venacla is already on the market in China, and can be found in the Category B medical insurance directory. The specification is 100mg*14 tablets and the price per box may be around RMB 5,000. The Turkish version of Venaclaoriginal drug, specifications100mg*112 tablets, sold overseas, costs around RMB 10,000 per box (the price may fluctuate due to exchange rates), which is even more expensive. Cheaper generic drugs are also sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs. The price of a box of 100mg*120 tablets produced by a Bangladeshi pharmaceutical factory is around RMB 4,000 (prices may fluctuate due to exchange rates).