What drug should I switch to after becoming resistant to Amivantamab?

For patients who develop resistance to Amivantumab (Amivantamab), treatment options will be influenced by multiple factors, including the patient's specific circumstances, molecular characteristics of the tumor, history of prior treatment, and available treatment options. Here are some possible treatment strategies, but please note that the best treatment plan should be determined by your doctor on an individual basis:

1.Chemotherapy: Chemotherapy is a traditional cancer treatment method that can deal with drug-resistant tumors to a certain extent. Doctors can choose different types of chemotherapy drugs to minimize tumor growth. However, chemotherapy may be associated with a range of adverse effects and should be used with caution.

2.Immunotherapy: Immunotherapy, such as PD-1 or PD-L1 inhibitors, has achieved significant breakthroughs in the treatment of some cancers. For some patients, immunotherapy may be an effective treatment option because it helps the patient's immune system better attack tumor cells.

3.Other targeted therapies: Other targeted therapies for lung cancer may be an option, especially for patients with specific molecular characteristics. Physicians can determine whether other targeted drugs may be suitable based on a patient's tumor genomics.

4.Clinical trials: Participation in clinical trials related to lung cancer is a possible treatment option. In clinical trials, novel treatments and drugs are being investigated, which may provide new opportunities for drug-resistant patients.

5.Supportive care: For some cases with high drug resistance, especially advanced lung cancer, supportive care is also very important. This includes pain management, emotional support and measures to improve quality of life.

Evantuzumab is not yet available in China, so patients cannot purchase it domestically and need to purchase it through foreign channels. There are only European versions of original drugs available abroad, and the price is relatively high, around 20,000 yuan.