What is the price of Vismodegib 2023?

Vismodegib (Vismodegib) is an orally active small molecule that inhibits thehedgehog signaling pathway by binding to and inhibiting the transmembrane protein smoothened homolog (SMO) . It was discovered through high-throughput screening of small molecule compound libraries and subsequent optimization through medicinal chemistry. Because it targets the hedgehog signaling pathway, vismodegib has antitumor activity in basal cell carcinoma.

The Hedgehog signaling pathway plays an important role in organ and tissue development during embryogenesis. It is then silenced in all cells and tissues except hair, skin and stem cells. However, dysregulated or abnormal Hedgehog signaling has been implicated in the pathogenesis of basal cell carcinoma. Vimodegib was approved by the FDA in 2012 for the treatment of basal cell carcinoma in adults. Common side effects of vismodegib in clinical trials included gastrointestinal disturbances (nausea, vomiting, diarrhea, constipation), muscle cramps, fatigue, hair loss, and dysgeusia (distorted taste).

The original drug of Vimodegib is not currently on the market in the country, so it cannot be included in medical insurance. Overseas, there are two common versions of Vimodegi original medicine, which are very expensive. The Turkish version of the original medicine, with a specification of 150mg*28 pills, may cost more than 10,000 yuan per box. The European version of the original medicine, with a specification of 150mg*28 pills, may cost more than 20,000 yuan per box (the price may fluctuate due to the exchange rate). The ingredients of the two drugs are the same. Currently, there is no generic version of Vimodegib produced or marketed. For more drug information and specific prices, please consult Yaode Medical Consultant.