The functions and efficacy of Temozolomide capsules

Temozolomide is a potent radiosensitizer and a key component of chemoradiotherapy for patients with newly diagnosed glioblastoma. The main advantage of temozolomide is its high efficacy against malignant brain glioma, and the main disadvantage is safety. Temozolomide is a drug that is highly toxic to surrounding tissues; therefore, nanoparticles are considered promising carriers that can eliminate this shortcoming while increasing the ability to penetrate the blood-brain barrier and reducing the metabolic rate of temozolomide.

The limited efficacy of temozolomide in the treatment of glioblastoma (GEM) is due in part to the high level of DNA repair activity of O-6-methylguanine-DNA methyltransferase (MGMT) in tumor cells, which transfers methyl groups to internal cysteine acceptor residues and reduces the effect of alkylating agents. Under physiological conditions, the increased half-life of temozolomide in the blood will result in greater accumulation of temozolomide in the brain and, therefore, in the glioblastoma region before conversion to MTIC. Therefore, the drug will be more effective and lower doses can be used to maintain current temozolomide therapeutic levels. This would make chemotherapy more promising, reduce side effects and toxicity, and extend patients' lives.

The original drug temozolomide has been launched in China and has entered the scope of Class B medical insurance. Common specificationsThe price of 100mg*1 tablet*5 bags per box may be around 2,000 yuan. The price of generic temozolomide drugs marketed overseas is relatively low, and its pharmaceutical ingredients are basically the same as those of the original temozolomide drug. For example, the price of a box of 100mg*5 produced by a Bangladeshi pharmaceutical factory may be around a few hundred yuan (the price may fluctuate due to exchange rates).