What are the side effects of Temsirolimus?

Temsirolimus should not be used by people who are allergic (hypersensitive) to temsirolimus, its metabolites (substances that are broken down into) including sirolimus (a drug used to prevent rejection of kidney transplants), polysorbate 80, or any other part of this medicine. Temsirolimus also should not be used in people with mantle cell lymphoma and moderate or severe liver problems.

In clinical studies, the most common (≥30%) adverse reactions of temsirolimus were rash, fatigue, mucositis, nausea, edema, and anorexia. The most common (≥30%) laboratory abnormalities observed with temsirolimus were anemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, lymphopenia, elevated alkaline phosphatase, elevated serum creatinine, hypophosphatemia, thrombocytopenia, elevated AST, and leukopenia. After the marketing of temsirolimus, adverse events such as angioedema, rhabdomyolysis, Stevens-Johnson syndrome, complex regional pain syndrome (reflex sympathetic dystrophy), pancreatitis, cholecystitis, and gallstones have occurred. If temsirolimus extravasates, it may cause swelling, pain, warmth, and erythema.

The original drug temsirolimus has not yet been marketed in China, and therefore cannot be included in domestic medical insurance. The original temsirolimus drug marketed overseas has a Turkish version and a European version. The ingredients of the two are basically the same. The price of each box of 30mg/1.2mL may be more than 10,000 yuan, and the price of 25mg/mL may be around 3,000 yuan per box (the price may fluctuate due to exchange rates). There is currently no generic version of temsirolimus available on the market. For more drug information and specific prices, please consult a medical consultant.