How to take Tazemetostat

Doctors will select patients with relapsed or refractory (R/R) follicular lymphoma (FL) to receive Tazemetostat based on whether there are EZH2 mutations at codons Y646, A682 or A692 in the patient's tumor specimens. The recommended dose of tazerestat is 800 mg twice daily, with or without food, until disease progression or unacceptable toxicity occurs. If the patient experiences adverse reactions after use, the use of tazerestat should be interrupted, reduced or stopped under the guidance of a doctor. The first dose of tazerestat can be reduced to 600 mg orally twice daily; the second dose can be reduced to 400 mg orally twice daily.

In patients who cannot tolerate 400 mg taken orally twice daily, tazerestat should be permanently discontinued. Avoid taking tazerestat concurrently with strong or moderate CYP3A inhibitors, and if avoidance cannot be avoided, adjust the drug dose. After discontinuing a moderate CYP3A inhibitor for 3 elimination half-lives, resume the dose of tazerestat that was taken before initiating the inhibitor. For patients taking 800 mg tazerestat orally twice daily, adjust the dose to 400 mg tazerestat orally twice daily; for patients taking tazerestat 600 mg orally twice daily Patients will adjust their dosage to 400 mg for the first dose and 200 mg for the second dose; patients who take tazerestat 400 mg orally twice a day will have their dose adjusted to 200 mg orally twice a day.

The original drug of tazerestat is not yet available in the domestic market and is therefore not included in medical insurance. Tazerestat US version of the original drug, specification200mg*240 tablets, which is marketed overseas, may cost around 200,000 yuan per bottle (the price may fluctuate due to exchange rates), which is very expensive. At present, there are no generic drugs of tazerestat produced and launched. For more drug information and specific prices, please consult the medical consultant of the drug.