What is sirolimus albumin-bound nanoparticle injection (FYARRO)?

Sirolimus albumin-bound nanoparticle injection (FYARRO) is an albumin-bound mTOR inhibitor administered in the form of an injection suspension. It is a U.S. Food and Drug Administration The first FDA-approved therapy to treat advanced malignant perivascular epithelioid cell tumor (PEComa), an extremely rare sarcoma. Advanced PEComa is a rare, aggressive soft tissue sarcoma for which there are currently no other approved treatments. PEComas are composed of histologically and immunohistochemically distinct epithelioid cells and are most commonly found in the visceral, retroperitoneal, and abdominopelvic sites.

Sirolimus in sirolimus albumin-bound nanoparticle injection is a mechanistic target inhibitor of rapamycin kinase (mTOR), a serine-threonine kinase that controls key cellular processes such as cell survival, growth and proliferation, and is often dysregulated in several human cancers. In vitro and in vivo studies have shown that inhibition of mTOR by sirolimus reduces cell proliferation, angiogenesis, and glucose uptake. In a nonclinical study of athymic mice bearing human tumor xenografts, intravenous administration of sirolimus albumin-bound nanoparticle injections resulted in higher sirolimus tumor accumulation, inhibition of mTOR targets in tumors, and tumor growth inhibition compared with oral administration of the same total weekly dose of sirolimus.

The original drug of sirolimus albumin-bound nanoparticle injection is a new type of drug for treating diseases. It is not currently on the market in China and therefore is not included in medical insurance. The US version of sirolimus albumin-bound nanoparticle injection Original drug, specifications The price of each 100mg tube may be around RMB 60,000 (the price may fluctuate due to the exchange rate), which is relatively expensive. Currently, there is no generic version of Sirolimus Albumin-Bound Nanoparticle Injection on the market. For more drug information and specific prices, please consult Yaode Medical Consultants.