What are the side effects of selumetinib?

In a clinical study of selumetinib in 74 pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromatosis (PN), the most common adverse reactions (≥40%) were vomiting, rash, abdominal pain, diarrhea, nausea, dry skin, fatigue, musculoskeletal pain, pyrexia, acne, stomatitis, headache, paronychia, and pruritus. Depending on the severity of the adverse reaction, selumetinib should be discontinued, dose reduced, or permanently discontinued.

Selumetinib may also cause cardiomyopathy, ocular toxicity (including retinal vein occlusion, retinal pigment epithelial detachment, and impaired vision), and increases in creatinine phosphokinase. Dose interruptions and dose reductions due to adverse reactions occurred in 80% and 24%, respectively, of patients treated with selumetinib and included vomiting, paronychia, diarrhea, nausea, abdominal pain, rash, skin infection, influenza-like illness, pyrexia, and weight gain. Adverse reactions leading to permanent dose discontinuation include increased creatine, weight gain, diarrhea, paronychia, malignant peripheral nerve sheath tumors, acute kidney injury, and skin ulcers.

SelumetinibThe original drug has been launched in China, but it has not yet entered the scope of medical insurance. SpecificationThe price of 10mg*60 tablets per box may be more than 20,000 yuan, which is relatively expensive. Selumetiniboriginal drug marketed overseas, specifications10mg*60 capsules per box may cost more than RMB 50,000 (the price may fluctuate due to exchange rates). The ingredients of the original selumetinib sold domestically and abroad are basically the same. There is currently no generic version of selumetinib produced and marketed. For more drug information and specific prices, please consult the medical consultant of Yaode.