How is selumetinib usually taken?

The recommended dose of selumetinib is 25 mg/m2 based on body surface area (BSA), taken orally twice daily (approximately every 12 hours) until disease progression or unacceptable toxicity occurs. Selumetinib usually needs to be taken on an empty stomach, with no food 2 hours before or 1 hour after each dose. If patients experience adverse reactions while taking selumetinib, doctors may adjust the dose of selumetinib. If the dose is reduced by two times, patients who cannot tolerate selumetinib should permanently discontinue it.

There is currently no dosage recommendation for patients with a body surface area less than 0.55m2; patients with a body surface area of 0.55-0.69m2 take 20mg orally in the morning and 10mg in the evening; patients with a body surface area between 0.7-0.89m2 take 20mg twice a day; patients with a body surface area between 0.90-1.09m2 take 25mg twice a day; Patients with a body surface area of 1.1-1.29 m2 take 30 mg orally twice a day; patients with a body surface area of 1.30-1.49 m2 take 35 mg orally twice a day; patients with a body surface area of 1.50-1.69 m2 take 40 mg orally twice a day; patients with a body surface area of 1.70-1.89 m2 take 45 mg orally twice a day; patients with a body surface area of 1.9 m2 or higher take 50 mg orally twice a day.

SelumetinibThe original drug has been launched in China, but it has not yet entered the scope of medical insurance. SpecificationThe price of 10mg*60 tablets per box may be more than 20,000 yuan, which is relatively expensive. Selumetiniboriginal drug marketed overseas, specifications10mg*60 capsules per box may cost more than RMB 50,000 (the price may fluctuate due to exchange rates). The ingredients of the original selumetinib sold domestically and abroad are basically the same. There is currently no generic version of selumetinib produced and marketed. For more drug information and specific prices, please consult the medical consultant of Yaode.