How to take Selinexor

Selinexor (Selinexor) When used in combination with bortezomib (Bortezomib) and dexamethasone (Dexamethasone), the recommended dose of selinexor is 100 mg orally administered once weekly on day 1 of each week until disease progression or unacceptable toxicity occurs, concurrently with bortezomib subcutaneously on day 1 of each week 1.3 mg/m2 for 4 weeks followed by 1 week off; or dexamethasone 20 mg orally twice weekly on days 1 and 2 of each week.

The recommended dose of selinesol when combined with dexamethasone is 80 mg orally on days 1 and 3 of each week until disease progression or unacceptable toxicity occurs, and 20 mg of selinesol orally on days 1 and 3 of each week in combination with dexamethasone. The recommended dose of selinesol for the treatment of diffuse large B-cell lymphoma (DLBCL) is 60 mg orally on days 1 and 3 per week until disease progression or unacceptable toxicity.

The original drug Seleniso has been launched in China, but it has not yet entered the scope of medical insurance. Specifications The price of 20mg*12 tablets per box may be around 20,000 yuan. The US version of the original Seleniso drug sold overseas, with a specification of 20mg*8 tablets, may cost more than 100,000 yuan per box (the price may fluctuate due to exchange rates), which is very expensive. Currently, there are also generic Selinisol drugs produced and marketed overseas. The price of a box of 20mg*16 tablets produced by a Lao pharmaceutical factory may be around RMB 4,000 (the price may fluctuate due to the exchange rate). Its drug ingredients are basically the same as those of the original drugs sold domestically and abroad.