Selinexor resistance management

Drug resistance is the biggest obstacle to treating multiple myeloma and many other cancersSelinexor (Selinexor) is an oral, selective inhibitor of XPO1-mediated nuclear export activity,Can be used to treat multiple myeloma (MM), diffuse largeB-cell lymphoma (DLBCL), and when patients develop resistance to selinesol, they may need to consider other treatment options.

Depending on the individual patient's circumstances, adjustments to the selinesol dose and dosing schedule may help overcome resistance. This may require working closely with your doctor. Combining selinesol with other anticancer drugs or treatments may increase the effectiveness of your treatment. For example, in combination with immunotherapy, chemotherapy drugs, or targeted therapy drugs. Researchers are actively searching for new targeted therapies to remedy the challenges that selinesol resistance may pose. These drugs may have different mechanisms of action and can effectively inhibit tumor growth. Everyone’s constitution is different and their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

The original drug Seleniso has been launched in China, but it has not yet entered the scope of medical insurance. Specifications The price of 20mg*12 tablets per box may be around 20,000 yuan. The US version of the original Seleniso drug sold overseas, with a specification of 20mg*8 tablets, may cost more than 100,000 yuan per box (the price may fluctuate due to exchange rates), which is very expensive. Currently, there are also generic Selinisol drugs produced and marketed overseas. The price of a box of 20mg*16 tablets produced by a Lao pharmaceutical factory may be around RMB 4,000 (the price may fluctuate due to the exchange rate). Its drug ingredients are basically the same as those of the original drugs sold domestically and abroad.