Can I take Relugolix alone for prostate cancer?

Androgen deprivation therapy (ADT) is a key component in the treatment of advanced prostate cancer, and when ADT is indicated, Relugolix is one of several possible options recommended in current National Comprehensive Cancer Network guidelines. Depending on the specific clinical setting, other options for ADT include orchiectomy, GnRH agonists (alone or with first-generation antiandrogens), or norrelix, with other agents (eg, abiraterone, docetaxel) also included in selected clinical settings. Although GnRH agonists or antagonists are preferred over orchiectomy because their effects are reversible and avoid the physical and psychological pain that can occur with surgical castration.

In the pivotal Phase III HERO trial in men with advanced prostate cancer, more than 90% of patients were treated with once-daily oral repagliflox for sustained castration from days 29 to 48 weeks of treatment, with effects consistent across a range of patient subgroups. The sustained castration rate of regaglic is not lower than that of leuprolide administered intramuscularly for 3 months, and exploratory analysis further shows that regaglic is superior to leuprolide. Using a loading dose and rapid drug absorption on day 1 of treatment, and consistent with the mechanism of GnRH antagonism, rapid suppression of testosterone was observed with regagrex, with 98.7% of patients reaching castration-resistant testosterone levels by day 15.

The original drug of Regogliflox has not yet been launched in the country, so it is not covered by medical insurance. There are European and Japanese versions of the original drug Rleglik available overseas. The ingredients of the two are basically the same. The price of the European version of 120mg*30 tablets per box may be around RMB 4,000, and the price of the Japanese version of 40mg*100 tablets per box may be around RMB 4,000 (the price may fluctuate due to exchange rates). Currently, there are no generic versions of Repagliflox produced and put on the market.