What disease does Fam-trastuzumab deruxtecan-nxki treat?

Fam-trastuzumab deruxtecan-nxki (Fam-trastuzumab deruxtecan-nxki) is approved by the U.S. Food and Drug Administration (FDA) for use in adult patients with the following diseases. It is not the same drug as trastuzumab (Herceptin, Herzuma). These drugs only contain trastuzumab and do not contain topoisomerase I inhibitors.

1. HER2-positive breast cancer: cannot be removed by surgery or has spread, and has received specific anti-HER2-based regimens.

2. HER2 low (IHC 1+ or IHC 2+/ISH-) breast cancer: cannot be removed by surgery or has spread to other parts of the body, and has received chemotherapy for spreading cancer or the cancer has recurred within 6 months after completing adjuvant chemotherapy.

3. HER2-positive gastric cancer: That is, adenocarcinoma of the stomach or gastroesophageal junction (GEJ), and the patient has received a trastuzumab-based regimen, and the cancer has spread to areas near your stomach (locally advanced) or has spread to other parts of the body (metastatic).

4. Non-small cell lung cancer (NSCLC): has an activating HER2 (ERBB2) mutation that cannot be removed by surgery, or the cancer has spread to other parts of the body (metastatic), and the patient has received systemic therapy and the activating HER2 (ERBB2) mutation is detected by an FDA-approved test.

Detrastuzumab is a new type of injectable anti-cancer drug. The original drug has been marketed in China, but it has not yet entered the scope of medical insurance. It is a strictly controlled drug. The domestic price is not yet clear. The Hong Kong version of Detrastuzumab Specifications may cost more than 10,000 yuan per box of 100mg. The Hong Kong original version of Detrastuzumab may be more than RMB 10,000 per box. Tocilizumab Specifications of the original drugThe price of 100mg per box may be around 15,000 yuan (the price may fluctuate due to the exchange rate). The ingredients of the two drugs are basically the same. There is currently no generic version of trastuzumab on the market. For more specific prices and drug information, please consult the medical consultant of the drug.