The difference between Fam-trastuzumab deruxtecan-nxki and Pertuzumab

Fam-trastuzumab deruxtecan-nxki and pertuzumab are two drugs used to treat HER2-positive breast cancer. They have different mechanisms of action and areas of use, but they are both administered through intravenous injection. Doctors will choose a suitable treatment plan based on the patient's specific situation and needs.

Trastuzumab is a targeted therapy that binds to the HER2 receptor and triggers apoptosis through the release of rapidly proliferating cytotoxins. It is used to treat unresectable and metastatic HER2-positive breast cancer that has been treated with anti-HER2 drugs, as well as HER2-low breast cancer that has been treated with chemotherapy. It may cause adverse reactions such as nausea, vomiting, fatigue, and hair loss. Serious adverse reactions include pulmonary toxicity and interstitial pneumonia. Pertuzumab is a recombinant humanized monoclonal antibody that binds to the extracellular dimerization domain II of HER2. It blocks the growth and spread of tumor cells by inhibiting the activation of the HER2 signaling pathway. It is often used in combination with trastuzumab and chemotherapy drugs for newly diagnosed HER2-positive breast cancer or as preoperative treatment. Common adverse reactions include diarrhea, rash, redness, fatigue, etc. Serious adverse reactions may include heart failure and interstitial lung disease.

Detrastuzumab is a new type of injectable anti-cancer drug. The original drug has been marketed in China, but it has not yet entered the scope of medical insurance. It is a strictly controlled drug. The domestic price is not yet clear. The Hong Kong version of Detrastuzumab Specifications may cost more than 10,000 yuan per box of 100mg. The Hong Kong original version of Detrastuzumab may be more than RMB 10,000 per box. Tocilizumab Specifications of the original drugThe price of 100mg per box may be around 15,000 yuan (the price may fluctuate due to the exchange rate). The ingredients of the two drugs are basically the same. There is currently no generic version of trastuzumab on the market. For more specific prices and drug information, please consult the medical consultant of the drug.