Will the blood pressure drop after taking Avatrombopag tablets for 35 days?

Avatrombopag (Avatrombopag) is a drug that treats thrombocytopenia by increasing the number of platelets in the body. Depending on the characteristics of the drug, platelet counts may gradually decrease after stopping taking avatrombopag tablets after 35 days. Factors that specifically affect platelet count include individual differences, severity of illness, and other possible causes of thrombocytopenia. After stopping the medication, platelet counts may gradually return to normal levels if there are no other interfering factors.

Avatrombopag is a novel small molecule thrombopoietin receptor agonist approved for the treatment of perioperative thrombocytopenia associated with chronic liver disease (CLD) or chronic immune thrombocytopenia (ITP) in adults. Avatrombopaghas similar pharmaceutical properties to eltrombopag, such as the same binding site for c-mannosylation of the thrombopoietin receptor (c-MPL), and the ability to induce differentiation and maturation of megakaryocytes (MKs), ultimately leading to increased platelet production.

The original drug of avatrombopag has been launched in China and has entered the scope of Class B medical insurance, but it is only reimbursed for eligible patients. The price of a common 20mg*15 tablets may be more than 7,000 yuan per box, while the original drug of avatrombopag marketed overseas is even more expensive. It is understood that there are generic drugs of avatrombopag available overseas, and their pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of a box of 20mg*30 tablets in Laos pharmaceutical production specifications may be around RMB 1,000 (the price may fluctuate due to exchange rates).