Does Vigabatrin make you drowsy?

Vigabatrin (Vigabatrin) is mainly used to treat refractory partial epilepsy and infantile spasms. Weight gain and transient sedation are the most common side effects, and it can also cause drowsiness and fatigue. Patients should be advised not to drive a car or operate other complex machinery until they are familiar with the effects of Vigabatrin on their ability to perform such activities.

Pooled data from two controlled trials of vigabatrin in adults showed that 24% of patients experienced drowsiness compared with 10% of placebo patients. In these same studies, 28% of patients experienced fatigue, compared with 15% of placebo patients. Nearly 1% of patients discontinued clinical trials due to sleepiness, and nearly 1% of patients discontinued clinical trials due to fatigue. Pooled data from three controlled trials of vigabatrin in pediatric patients showed that drowsiness occurred in 6% of patients compared with 5% of placebo patients. In these same studies, 10% of patients experienced fatigue, compared with 7% of placebo patients. No patients discontinued the clinical trial due to sleepiness or fatigue.

The original Vigabatrin drug has not yet been launched in China, so it is not included in medical insurance. The Hong Kong version of the specificationsThe price of 500mg*100 bags per box may be more than 1,000 yuan (the price may fluctuate due to exchange rate effects). It is reported that an Indian chemical generic drug vigabatrin powder is on the domestic market. The price of each box of 500mg*50 bags may be more than 3,000 yuan. Its pharmaceutical ingredients are basically the same as those of the original drug. The Turkish version of Vigabatrin currently sold overseas may cost more than RMB 1,000 per box of 500mg*100 bags (the price may fluctuate due to exchange rates).