Domestic launch date of Axitinib

Axitinib (Axitinib) is an oral targeted therapy drug, mainly used for the treatment of renal cell carcinoma (RCC, kidney cancer) in adult patients. As a tyrosine kinase inhibitor, axitinib interferes with the blood supply of tumors and blocks angiogenesis by inhibiting targets such as vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3), thus limiting the growth and spread of tumors.

Axitinib was approved by the U.S.FDA Approved for marketing, was approved for marketing by the State Food and Drug Administration of China on April April 29 in 2015. Axitinib has been launched in China and has been included in medical insurance. Patients can purchase it domestically. The price of 5mg*28 tablets is about 5,000 to 6,000 yuan. For specific prices, please consult the local hospital pharmacy. There are original and generic axitinib drugs abroad. The original drug is Pfizer's original drug, and the price is about 6,000 yuan; the generic drugs are mainly Bangladeshi generics and Indian generics. The price of Bangladeshi generics in 5mg*60 tablets is more than 1,000 yuan, and the price of Indian generics is around a few hundred yuan. The ingredients of original drugs and generic drugs are basically the same.

Axitinib is widely used to treat renal cell carcinoma, especially in patients with advanced or metastatic renal cell carcinoma that has become resistant to previous first-line treatments.

Axitinib specifically acts on the tumor angiogenesis pathway and reduces the activity of vascular endothelial growth factors, thereby slowing down the blood supply of tumors and inhibiting tumor growth. The drug is rapidly absorbed after oral administration, reaching peak plasma concentrations. It is mainly metabolized in the liver and forms major metabolites.

The usual dose of axitinib is oral administration 2 times daily, usually at least 2 hours after breakfast and dinner. Dosage may be adjusted based on the patient's specific condition.

Axitinib may cause a series of side effects, including but not limited to hypertension, hand-foot syndrome, proteinuria, fatigue, etc. Patients need to pay close attention to these side effects during medication and report them to their doctor in a timely manner.