Instructions for Omarigliptin

1. Name: Omarigliptin, Omarigliptin, Omarigliptin, MARIZEV

2. Indications:

Omarigliptin (Omarigliptin) is suitable for the treatment of adult patients with type 2 diabetes.

3. Usage and dosage:

1. Recommended dosage: The recommended dosage of ologliptin is 25 mg taken orally once a week. If the patient misses a dose, take it as soon as he remembers. Then take your next dose according to your normal dosing schedule. Never take a double dose to make up for a missed dose.

2. Dose adjustment: If a patient experiences adverse reactions when using ologliptin, the doctor may adjust the drug dose according to the severity of the condition. For example, for patients with severe kidney damage, the dose may be reduced to oral once a week 12.5 mg.

4. Adverse reactions:

In clinical trials of ologliptin, common adverse reactions include hypoglycemia, constipation, etc. There are no case reports of death, serious adverse events or hypoglycemia.

5. Storage:

The storage temperature of ologliptin is normal temperature and can be stored below 30℃.

6. Taboo:

Omarigliptin is contraindicated in patients who are allergic to Omarigliptin or any of its components.

7. Mechanism of action:

Ologliptin is a small molecule dipeptidyl peptidase4 (DPP-4) inhibitor. The incretins glucagon-like peptide1 (GLP-1) and glucose-dependent insulin secretion-stimulating polypeptide (GIP) are hormones involved in maintaining glucose homeostasis. Dipeptidyl peptidase4 (DPP-4) inhibitors delay the inactivation of incretin hormones and increase the concentration of active incretin, thereby enhancing the blood glucose secretagogue and glucagon concentration-lowering effects in a hyperglycemic manner and improving glycemic control.