How much does generic Sotorasib cost?

Sotorasib, also known asAMG 510, is a drug used to treat patients with certain KRAS Novel anticancer drugs for G12Cmutated advanced non-small cell lung cancer (NSCLC). KRAS G12CThe KRAS G12C mutation is a mutation that is prevalent in a variety of cancers, including lung cancer, colorectal cancer, and other solid tumors.

The original drug of sotorasibu has not yet been launched in China, so patients cannot purchase it domestically and need to purchase sotorasibu through overseas channels. The price of the original research version of sotorasibu in Hong Kong, China, is 120mg*240 tablets, which is around 8 million. The price of the European version of the original research drug with the same specifications is around 4 million, which is relatively expensive. The cheaper ones are the generic drugs marketed abroad. For example, the price of generic drugs in Laos and Bangladesh is around two to three thousand yuan. The price is relatively cheap, and the ingredients of foreign generic drugs are basically the same as the original drugs.

Sotoracib is unique in that it is the first drug to directly inhibit the KRAS G12C mutation, which has been considered difficult to intervene. The KRAS gene encodes a protein that promotes cell proliferation, and the KRAS G12C mutation puts this protein in an overactive state, driving the growth of cancer cells.

Sotorasiib inhibits the growth and spread of cancer cells by binding to the KRAS G12C protein and preventing its activity. The development of this drug represents an important breakthrough in cancer treatment, as scientists have long struggled to find ways to effectively intervene in KRAS mutations.

Clinical trials show that sotorasiib is effective against NSCLC with KRAS G12C mutationThe patients had significant anti-tumor activity. The drug has shown encouraging efficacy in clinical studies, providing new hope for patients who have so far lacked effective treatment options.