How many boxes of Tepotinib should you take a month?

Tepotinib is an orally administered tyrosine kinase inhibitor that targets the MET tyrosine kinase receptor, including variants resulting from exon 14 skipping. On February 3, 2021, tepotinib received accelerated approval from the U.S. Food and Drug Administration (FDA) for the treatment of adults with metastatic non-small cell lung cancer carrying MET exon 14 skipping alterations. Accelerated approval does not include people with MET-amplified non-small cell lung cancer.

For tepotinib, the recommended dosing regimen of 450 mg once daily (free base form, equivalent to 500 mg of tepotinib hydrochloride hydrate) is based on a dose-finding study were selected as a result of which the maximum tolerated dose (MTD) was not reached at the 1400 mg once-daily dose and dose-limiting toxicities were only observed at the 1000 mg and 1400 mg once-daily dose levels. TepotinibThe common specifications of the original drug are:225mg*30 tablets. It is estimated that patients need to take two boxes a month, provided that there are no side effects that cause the drug to be discontinued during drug treatment.

The original drug Tepotinib is already on the market in China, but it is not yet eligible for medical insurance. Tepotinib Original drug currently marketed overseas is relatively expensive, and the price of each box of 225mg*30 tablets may be around RMB 80,000 (the price may fluctuate due to exchange rates). There are already generic Tepotinib drugs produced in other countries. The ingredients of these generic drugs are basically the same as those of the original drug, but the price is relatively cheap. For example, the price of 225mg*60 tablets produced by a Laos pharmaceutical factory may be more than 8,000 yuan per box (the price may fluctuate due to exchange rates).