Are there any serious side effects of Upadacitinib?

Upadacitinib (Upadacitinib) carries warnings about the risk of serious infection, increased all-cause mortality, malignancy, adverse cardiovascular events, and thrombosis. Warnings and precautions related to upadatinib include serious infections, allergic reactions, gastrointestinal (GI) perforation, laboratory abnormalities, and embryo-fetal toxicity.

Side effects in patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and nonradiographic axial spondyloarthritis include upper respiratory tract infection, shingles, herpes simplex, bronchitis, nausea, cough, fever, and acne. Side effects in patients with atopic dermatitis include upper respiratory tract infection, acne, herpes simplex, headache, elevated blood creatine phosphokinase, cough, hypersensitivity reactions, folliculitis, nausea, abdominal pain, pyrexia, weight gain, herpes zoster, influenza, fatigue, neutropenia, myalgia, and influenza-like illness. Side effects in patients with ulcerative colitis include upper respiratory tract infection, elevated blood creatine phosphokinase, acne, neutropenia, elevated liver enzymes, and rash. Side effects in people with Crohn's disease include upper respiratory tract infections, anemia, fever, acne, shingles, and headaches.

The original drug Upatinib has been launched in China, and has subsequently entered the scope of Class B medical insurance. Only eligible patients can be reimbursed. Specifications The price of each box of 15mg*28 tablets may be around RMB 3,000. The European version of the original drug sold overseas is priced at more than 20,000 yuan for 15mg*30 tablets (the price may fluctuate due to exchange rates), which is expensive. Cheaper upadatinib generic drugs are also sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of 15mg*30 tablets produced by Bangladesh pharmaceutical factory is around 900 yuan (the price may fluctuate due to the exchange rate).