The best time to take Dasatinib

Dasatinib (Dasatinib) is an oral tablet that is usually taken once daily, in the morning or evening, with or without food. Take dasatinib at about the same time each day. Take dasatinib exactly as directed. Do not take more or less than prescribed by your doctor. Doctors will tell patients to swallow the tablets whole; do not cut, chew, or crush them. If you cannot swallow the tablet whole, or if you are giving this medication to a child, ask your doctor how to take dasatinib tablets.

At 100mg once daily (QD), the steady-state maximum concentration (Cmax) is 82.2ng/mL (CV% 69%), and the area under the plasma drug concentration-time curve (AUC) is 397ng/mL*hr (CV% 55%). The clearance of dasatinib was found to be unchanged over time. When administered as tablets dispersed in juice to adult healthy subjects, the adjusted geometric mean ratio of Cmax was 0.97 and the adjusted geometric mean ratio of AUC was 0.84 compared to intact tablets. The maximum plasma concentration (Cmax) of dasatinib is observed between 0.5 hours and 6 hours (Tmax) after oral administration. A high-fat meal increased the mean AUC of a single 100 mg dose of dasatinib by 14%. The total calories of high-fat food are 985 kcal. Patients should wear latex or nitrile gloves when handling accidentally crushed or broken tablets to prevent contact with the medication.

The original drug of dasatinib has been launched in China and is included in the medical insurance. Currently, reimbursement is only available to eligible patients. Common specifications The price of each box of 50mg*60 tablets may be around RMB 10,000. The original drug overseas is even more expensive. Dasatinib generics are also sold overseas. The ingredients of the drug are basically the same as those sold domestically and abroad, but the price is cheap. For example, the price of a box of 50mg*60 tablets produced by an Indian pharmaceutical factory may be several hundred yuan (the price may fluctuate due to exchange rates).