What are the precautions for Nintedanib?

Nintedanib(Nintedanib)is a prescription drug indicated for idiopathic pulmonary fibrosis and chronic fibrotic interstitial lung disease with a progressive phenotype(ILDs), and can also slow down the decline in lung function in patients with systemic sclerosis-related interstitial lung disease(SSc-ILD). What are the precautions for Nintedanib(Nintedanib)?

1.Possiblehepatotoxicity may occur. Liver function tests should be performed before the start, regularly for the first 3 months, and regularly thereafter, or according to clinical indications. Liver enzymes should be tested immediately in patients with symptoms of liver dysfunction, including fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice.

2.Possiblegastrointestinal effects may occur. Diarrhea, nausea, and vomiting may occur. In clinical studies, diarrhea occurred frequently in patients receiving nintedanib, usually within the first 3 months of treatment. Treat gastrointestinal adverse reactions with appropriate supportive care when necessary. If diarrhea occurs or nausea or vomiting persists despite appropriate supportive care, temporary discontinuation or dose reduction may be necessary. Discontinue nintedanib if diarrhea persists despite symptomatic treatment or if severe nausea or vomiting does not resolve.

3.May cause harm to the fetus. Demonstrated embryotoxicity and teratogenicity in animals. Avoid pregnancy during treatment and for at least 3 months after discontinuation of treatment, and inform pregnant women of the potential fetal harm.

4.Possibility ofarterial thromboembolic events. Interruption of treatment should be considered in patients who develop signs or symptoms of acute myocardial ischemia.

5.May increase the risk of bleeding.

6.May increase the risk of gastrointestinal perforation. Use with caution in patients who have had recent abdominal surgery, have a history of diverticular disease, or are receiving concomitant treatment with corticosteroids or NSAIAs. Use in patients with risk factors for gastrointestinal perforation only if the potential benefits outweigh the risks. If gastrointestinal perforation occurs, discontinuenintedanib.

7.Nephrotic range proteinuria may occur. Reports of nephrotic-range proteinuria during the postmarketing period. The available histologic findings were consistent with glomerular microangiopathy with or without renal thrombosis. Nintedanib Proteinuria improves after discontinuation of treatment, However, in some cases residual proteinuria may occur, Consider discontinuing treatment in patients who develop new or worsening proteinuria.

There are generic drugs abroad, and they are produced in India, Bangladesh, and Laos. If patients buy overseas generic drugs, they can first go to overseas hospital pharmacies to buy them themselves, and secondly contact them through regular domestic overseas pharmaceutical consultation machines. The retail price of BDR pharmaceuticals in India is about 400 yuan for 30 tablets of 150 mg, and the retail price at pharmacies is about 400 yuan for 100 mg of 30 tablets. The retail price of Beacon Pharmaceutical in Bangladesh is 3,000 yuan for 150 mg and 60 tablets, and for ASEAN Pharmaceutical in Laos is about 6,000 yuan for 100 mg and 60 tablets, and for 100 mg and 60 tablets, it is about 7,760 yuan. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.

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