How long does it take for mitotane to take effect?

Mitotane is indicated for the treatment of inoperable functional or non-functioning adrenocortical carcinoma. Generally, a preliminary efficacy evaluation can be carried out after taking mitotane for about a month. If the treatment results show that it is effective, it should be continued for a long time until drug resistance appears.

The recommended initial dose of mitotane is 2g to 6g taken orally in three or four divided doses per day. Gradually increase the dose until the blood concentration reaches 14-20mg/L, or reaches the tolerance level. Administer under the supervision of an experienced cancer chemotherapy physician and in a facility equipped for complication management. This drug suppresses adrenal function. Treatment is temporarily discontinued after shock or severe trauma and exogenous steroids are administered, as drug-suppressed adrenal function may not return immediately. Mitotane is an adrenergic agent that inhibits selected adrenocortical function by binding to mitochondrial proteins, causing adrenal atrophy and tumor death, with atrophy observed in the zona fasciculata and zona reticularis. Mitotane, used to treat adrenal cancer, works by slowing the growth or killing adrenal cells and reducing the amount of hormones produced by the adrenal glands.

How is mitotane used?

Take this medication by mouth with or without food, usually 3 or 4 times daily as directed by your doctor. Dosage is based on physical condition and response to treatment. Use this medication regularly to get the most benefit. To aid memory, take it at the same time every day. Do not increase your dose or use this medication more often or for longer than prescribed. Your condition will not improve faster, and your risk of serious side effects will increase. Learn how to safely handle and dispose of this medication and its container. Because this drug can be absorbed through the skin and lungs and may cause harm to an unborn baby, women who are or may become pregnant should not use this drug or breathe the dust in the tablets.

There are generic drugs that are officially on the market in Laos. The retail price is about 500mg100 tablets3 about one thousand. If you want to get more high-quality information, you can contact Yaode. Yade will do its best to learn more about high-quality overseas drugs for you.