Can mitotane completely cure adrenocortical cancer?

Mitotane is the only drug approved for the treatment of inoperable or postoperative local recurrence and metastasis of adrenocortical carcinoma. Mitotane cannot cure adrenocortical cancer. It can cause atrophy or necrosis of the adrenal cortex, thereby alleviating physical symptoms and delaying the progression of the disease.

Trials have shown that it is effective in adrenocortical cancer that cannot be surgically removed or has distant metastasis. The objective effective rate is 34% to 61%, and the median remission period is 6 to 7 months. For functional adrenocortical cancer, it can alleviate the symptoms of cortical hyperfunction, shrink tumors, and prolong life.

Dizziness, drowsiness, nausea, vomiting, diarrhea, loss of appetite, or weakness may occur while taking mitotane. If these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, stand up slowly when rising from a sitting or lying position. Tell your doctor right away if you have any serious side effects, including :unusual/rapid weight loss, mental/mood changes (such as depression, confusion) vision changes (Such as blurred vision, double vision), skin color changes, fainting, easy bleeding// span>Bruising, hematuria, signs of ovarian cysts(such as unusual vaginal bleeding, pelvic pain). Mitotane usually causes a rash, which is usually not serious. However, it may not be possible to tell the difference other than a rash that may be a sign of a severe reaction. If any rash occurs, seek medical attention immediately. A very serious allergic reaction to this drug is rare. However, if you notice any symptoms of a severe allergic reaction, including:rash, itching/swelling(Special Especially face/tongue/throat), severe dizziness, difficulty breathing, please seek medical help immediately.

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