What is bedaquiline?

Bedaquiline (Bedaquiline) is an anti-tuberculosis drug used in a 3 drug combination regimen including pretomanid and linezolid for the treatment of extensive drug resistance (XDR) Pulmonary tuberculosis(i.e., caused by Mycobacterium tuberculosis that is resistant to isoniazid, rifampicin, any fluoroquinolone, and at least one injectable anti-tuberculosis drug)or intolerant or unresponsive to treatmentMDRpulmonary tuberculosis. WHO states that pretomanid, bedaquiline and linezolid (also known as BPaL) can be used to treat patients who have not previously received bedaquiline or linezolid.(or 2weeks)and there is evidence that MDR strains are also resistant to fluoroquinolonesMDR tuberculosis.

Before and during bedaquilinetreatment, obtain laboratory tests to evaluate liver function and to evaluate for signs and symptoms of liver disease. Assess serum electrolyte concentrations before initiating treatment and perform electrocardiograms before and during treatment. Use direct observation(supervision)therapy(DOT)administration.

When taking bedaquiline, take orally with food and swallow it with water 100 mg tablets. For patients who are unable to swallow tablets, 20mg tablets may be dispersed in water and taken with a drink or soft food. Place no more than five 20mg tablets into a clean cup, add 5ml(as a teaspoon)of water and mix well to disperse the tablets. Swallow the resulting mixture immediately with food or further mix with a small amount(such as a teaspoon)a beverage(such as dairy, apple juice, orange juice, cranberry juice, carbonated drinks) or soft drink(Such as yogurt, applesauce, mashed banana, oatmeal)Mix. If the dose requires more than five 20-mg tablets, repeat this procedure until the total dose required is reached. To ensure the full dose is taken, add an extra small amount of drink or soft food to the cup to disperse any remaining residue, and swallow immediately. or Crush an appropriate number of 20mg tablets, mix with soft food (such as yogurt, applesauce, mashed bananas, oatmeal)and swallow immediately. To ensure the full dose is taken, add an extra small amount of drink or soft food to the container to disperse any residue and swallow immediately. If using a feeding tube, place no more than 5tablets20mg into a container with 50ml of non-carbonated water and mix thoroughly to disperse the tablets, the mixture should be white to almost white with visible particles. Administer via feeding tube immediately, if the dose requires more than five 20-mgtablets, repeat this procedure until the total desired dose is reached. To ensure that the full dose is taken, use an additional 25ml of water to flush the container and flush the feeding tube.

There is an original drug in Russia, the specification is 188 tablets, half a year’s supply, one box is about 1 around 14,000 to 50,000. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.

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