Bedaquiline usage and dosage

Bedaquiline is a new anti-tuberculosis drug with significant minimum inhibitory concentrations (MICs) for both drug-sensitive and drug-resistant tuberculosis. Bedaquilineis used with other drugs to treat tuberculosis that is resistant to other antibacterial drugs. Bedaquiline is suitable for adults and children who are at least5 years old and weigh at least15kg.

The usual adult dose of anti-tuberculosis drugs is 1week and 2week:400 taken orally daily mg, week 3weeks 24:3 times per weekorally200 mg, with at least 48 hours between doses, and treatment duration: 24 weeks. Common pediatric doses of antituberculosis drugs12 years and older and 30kg and above:Week 1 and Week 2:Orally administered 400 mg daily, 3Thickly 24weeks:3oral times per week200 mg, with at least 48 hours between doses, and treatment duration: 24 weeks. If a missed dose occurs:Week 1 and Week 2:Skip the missed dose and continue the daily dosing schedule without taking double the missed dose the next day. No. 3-24Weekly:Take the missed dose as soon as possible, then resume a regimen of 3 times per week.

Take bedaquiline strictly as prescribed by your doctor. Follow all directions on your prescription label, and read any medication guides or inserts. Take with food, with water 100 mg tablet, Swallow the tablet whole without crushing, chewing or breaking it. If desired, 20mg tablets may be broken along the dividing line. If you cannot swallow the 20 mg tablet, dissolve the tablet in water and mix it with a drink or soft food. Read and carefully follow all directions for mixing the 20 mg tablet to make it easier to swallow. Bedaquiline Dosage is based on the child or teen's weight and your child's dose may change if your child's weight has gained or lost. Even if symptoms improve quickly, use bedaquiline for the full time prescribed; skipping doses increases the risk of an infection that becomes resistant to the drug. Bedaquilinemust be used in combination with other tuberculosis drugs and should not be used alone. Use all medicines as directed, and read all medication guides you receive.Do not change your dosage or stop taking your medicines without your doctor's advice. Because the therapeutic efficacy of bedaquiline may be reduced due to reduced systemic exposure, concomitant use of strong CYP3A4 inducers, such as rifamycins, should be avoided during bedaquiline treatment. span>That is, rifampicin, rifapentine and rifabutin)or moderateCYP3A4 inducers.

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