What disease does the newly launched dabrafenib treat?

Dabrafenib is an inhibitor of some mutated BRAF kinases, including BRAF V600E and V600K mutations. As a single agent, dabrafenib is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutations detected in an U.S. Food and Drug Administration (FDA)approved test. Dabrafenib can also be used in combination with trametinib, including:

1. Treatment of patients with unresectable or metastatic melanoma who have BRAF V600E or V600K mutations detected in FDA-approved trials, and adjuvant therapy for patients with melanoma that involves lymph nodes after complete resection;

2. Treatment of patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation;

3. Treatment of patients with locally advanced or metastatic anaplastic thyroid cancer (ATC) who have BRAF V600E mutation and no satisfactory locoregional treatment options;

4. Treatment of adult and pediatric patients 6 years of age and older with unresectable or metastatic BRAF V600E-mutant solid tumors who have progressed after prior therapy and for whom satisfactory alternative treatment options are not available.

5. Treatment of pediatric patients 1 year of age and older with BRAF V600E-mutated low-grade glioma (LGG) who require systemic therapy.

The original drug of dabrafenib is relatively expensive and has been covered by medical insurance since it was launched in China. Currently only eligible patients are reimbursed. The price of each box of 50mg*120 capsules may be around around 10,000. Turkish version of dabrafenib original drug sold overseas, specificationsThe price of each box of 75mg*120 capsules may be around 10,000 (the price may fluctuate due to exchange rates). There are also relatively cheap generics of dabrafenib sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, Specifications produced by Laos Pharmaceutical Factory The price of 75mg*120 tablets per box may be more than 4,000 yuan (the price may fluctuate due to exchange rates).