Are the side effects of dabrafenib serious?

Common adverse reactions to dabrafenib as a single agent include hyperkeratosis, headache, pyrexia, arthralgia, papilloma, alopecia, and palmar-plantar dysesthesia syndrome. Common adverse reactions of the combination of dabrafenib and trametinib are related to the type of cancer. Side effects that occur in unresectable or metastatic melanoma include fever, rash, chills, headache, joint pain and cough. Side effects that occur in its adjuvant treatment include fever, fatigue, nausea, headache, rash, chills, diarrhea, vomiting, joint pain and myalgia.

Side effects seen in non-small cell lung cancer include fever, fatigue, nausea, vomiting, diarrhea, dry skin, decreased appetite, edema, rash, chills, bleeding, cough, and difficulty breathing; side effects seen in adults with solid tumors include fever, fatigue, nausea, rash, chills , headache, bleeding, cough, vomiting, constipation, diarrhea, myalgia, arthralgia, and edema; side effects seen in pediatric patients with low-grade glioma include fever, rash, headache, vomiting, musculoskeletal pain, fatigue, diarrhea, dry skin, nausea, bleeding, abdominal pain, and acneiform dermatitis.

The original drug of dabrafenib is relatively expensive and has been covered by medical insurance since it was launched in China. Currently only eligible patients are reimbursed. The price of each box of 50mg*120 capsules may be around around 10,000. The Turkish version of the original drug Dabrafenib sold overseas, Specifications 75mg*120 capsules, may cost around 10,000 per box (the price may fluctuate due to exchange rates). There are also relatively cheap generics of dabrafenib sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, Specifications produced by Laos Pharmaceutical Factory The price of 75mg*120 tablets per box may be more than 4,000 yuan (the price may fluctuate due to exchange rates).