How to reduce the dosage of dabrafenib and trametinib

If a patient develops intolerable adverse reactions after treatment with Dabrafenib and trametinib, the doctor may adjust the dose of the drug, such as reducing, interrupting or stopping treatment, based on the severity of the condition. Dabrafenib is usually available as a capsule, while trametinib is available as a tablet, and both are administered orally, with or without food.

For adult patients treated with dabrafenib, if the recommended dose is 150 mg orally twice a day, the first dose can be reduced to 100 mg orally twice a day; the second dose can be reduced to 75 mg orally twice a day; the third dose can be reduced to 50 mg orally twice a day; if dabrafenib capsules 50 mg orally twice a day are not tolerated, please permanently discontinue treatment. For adult patients treated with trametinib , if the recommended dose is 2 mg orally once daily, the first dose may be reduced to 1.5 mg orally once daily; the second dose may be reduced to 1 mg orally once daily; and the third dose may be reduced to 50 mg orally twice daily; if up to two dose reductions are not tolerated, permanently discontinue trametinib tablets.

The original drug of dabrafenib is relatively expensive and has been covered by medical insurance since it was launched in China. Currently only eligible patients are reimbursed. The price of each box of 50mg*120 capsules may be around around 10,000. The Turkish version of the original drug Dabrafenib sold overseas, Specifications 75mg*120 capsules, may cost around 10,000 per box (the price may fluctuate due to exchange rates). There are also relatively cheap generics of dabrafenib sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, Specifications produced by Laos Pharmaceutical Factory The price of 75mg*120 tablets per box may be more than 4,000 yuan (the price may fluctuate due to exchange rates).