How to take dabrafenib for children

Dabrafenib is available in capsules and oral suspension tablets. The recommended dose for pediatric patients weighing 26-37 kg is 75 mg orally twice a day; for pediatric patients weighing 38-50 kg, the recommended dose is 100 mg orally twice a day; for pediatric patients weighing over 51 kg, the recommended dose is 150 mg orally twice a day; for patients weighing less than 26 kg, the recommended dose of dabrafenib has not yet been determined. Pediatric patients should take dabrafenib capsules at least 1 hour before or 2 hours after a meal, and at the same time every day, approximately 12 hours apart.

Patients may prepare a suspension of 1 to 4 dabrafenib oral suspension tablets and approximately 10 mL of water to prepare a suspension of 5 to 15 tablets in the cup provided. Gently stir the water and the prescribed number of tablets with a teaspoon until the tablets are completely dissolved. The tablets may take at least 3 minutes to completely dissolve. Once the oral suspension tablets are dissolved, the suspension will be cloudy white in color. Administer the suspension from a cup, oral administration syringe, or feeding tube immediately after preparation. Discard the suspension if not administered within 30 minutes of preparation.

The recommended dose of dabrafenib oral suspension tablets for pediatric patients is based on body weight, The recommended dose for patients 8-9kg is 20mg orally twice daily, for patients 10-13kg the recommended dose is 30mg; for patients 14-17kg the recommended dose is 40mg; for patients 18-21kg the recommended dose is 50mg; for patients 22-25kg the recommended dose is 60mg; The recommended dose for patients 26-29kg is 70mg; for patients 30-33kg, the recommended dose is 80mg; for patients 34-37kg, the recommended dose is 90mg; for patients 38-41kg, the recommended dose is 100mg; for patients 42-45kg, the recommended dose is 110mg; for patients 46-50kg, the recommended dose is 130mg; for patients >51kg, the recommended dose is 150mg.

The original drug of dabrafenib is relatively expensive and has been covered by medical insurance since it was launched in China. Currently only eligible patients are reimbursed. The price of each box of 50mg*120 capsules may be around around 10,000. Turkish version of dabrafenib original drug sold overseas, specificationsThe price of each box of 75mg*120 capsules may be around 10,000 (the price may fluctuate due to exchange rates). There are also relatively cheap generics of dabrafenib sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, Specifications produced by Laos Pharmaceutical Factory The price of 75mg*120 tablets per box may be more than 4,000 yuan (the price may fluctuate due to exchange rates).