Selumetinib Instructions

1. Indications

Selumetinibis aMEK 1/2Inhibitor indicated for the treatment of symptomatic, inoperable plexiform neurofibromas (PN) and neurofibromatosis (NF1) in pediatric patients.

2. Usage and dosage

For neurofibromatosis type 1(NF1): The recommended dose for children 2 years and older is usually per square meter of body surface area25mg(mg/m2), taken 2 times a day, at least 12 hours apart.

If you miss a dose of this medicine, take it as soon as possible. However, if it is time for your next dose, skip the missed dose and return to your regular dosing schedule, Do not double your dose.

Three. Contraindications

None

Four. side effects

Common side effects of selumetinib include reduced ejection fraction (23%), sinus tachycardia (20%) , increased blood pressure, dermatitis acneiform (54%) , maculopapular rash span>(39%), eczema(28%), vomiting(82%), abdominal pain(76%), diarrhea(Up to77%), nausea(73%), oral ulcers(50%), constipation(34%), elevated lipase(32%), dry mouth(20%), elevated amylase(18%), perforation, colitis, intestinal obstruction, intestinal obstruction, reduced albumin(51%), reduced hemoglobin(41%), medium Neutropenia(33%), lymphopenia(20%), increased aspartate aminotransferase(41%), increased alanine aminotransferase(35%), increased potassium(27%) , decreased appetite(22%), weight gain(less than20%), decreased potassium(18%), increased alkaline phosphatase(18%), increased sodium(18%), decreased sodium( 16%), Increased creatine phosphokinase (Up to79%), Musculoskeletal pain, including limb, back and neck pain (58%), Headache(48%), Blurred vision, photophobia, cataracts and high intraocular pressure (20% lower than )< /span>, Retinal vein occlusion(RVO), retinal pigment epithelial detachment(RPED), central serous retinopathy, epistaxis( 28%), dyspnea, hematuria(22%), proteinuria(22%), acute kidney injury(20%), etc.

5. Note

1.Using this drug during pregnancy can harm the fetus. Use effective contraception to prevent pregnancy during treatment and for at least 1 weeks after the last dose. Men who are taking this medicine and whose female partners may become pregnant must use effective contraception during treatment and for at least 1 weeks after the last dose of this medicine.

2.This medicine may cause heart problems. Contact your doctor right away if you have chest discomfort or pain, dizziness or fainting, a fast, irregular, or pounding heartbeat, swelling of your feet or lower legs, difficulty breathing, or unusual fatigue or weakness.

3.If you experience eye pain or vision changes during treatment, please contact your doctor immediately. These may be signs of serious eye problems.

4.This medicine may cause diarrhea, which may be severe in some cases. Do not take any medicine for diarrhea without checking with your doctor.

5.Contact your doctor immediately if you have severe rash, acne, or redness, swelling, peeling, or tenderness on your hands or feet.

6.Contact your doctor immediately if you have dark urine, fever, muscle spasms or spasms, muscle pain or stiffness, or unusual fatigue or weakness. These may be symptoms of a serious muscle problem called rhabdomyolysis, which can lead to kidney problems.

7.This medicine may cause bleeding problems. Tell your doctor if you have bleeding gums, coughing up blood, difficulty breathing or swallowing, dizziness, headache, increased menstrual flow or vaginal bleeding, nosebleeds, persistent bleeding from a cut, red or dark brown urine, or red or black tarry stools.

6. Mechanism of action

Selumetinib is a kinase inhibitor that is selective for mitogen-activated protein kinase kinase (MAPK kinase or MEK) isoforms 1 and 2. These enzymes are part of the MAPK/ERK pathway, which regulates cell proliferation (growth and division) and are overactive in many types of cancer.

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