Which drug should be chosen for treatment after Sotorasib resistance?

When a patient experiences Sotorasib resistance, the choice of treatment will depend on multiple factors, including the individual patient's condition, the characteristics of the cancer, and the availability of other treatment options. Here are some possible treatment options:

1. Adagrasib (Adagrasib): Adagrasib is another drug that targets the KRAS G12C mutation, similar to sotorasib. For patients who are resistant to sotoracib, adagrasiib may be a viable option. However, patients need to be fully evaluated before switching medications to determine if adagrasib is appropriate.

2. Immunotherapy: Immunotherapy is a method of fighting cancer by activating the patient's own immune system. For example, PD-1 inhibitors or PD-L1 inhibitors may be used in some patients with non-small cell lung cancer. Immunotherapy may be effective in some cases against KRAS mutant cancers.

3. Chemotherapy: Traditional chemotherapy remains a treatment option, especially after failure of targeted therapies. Chemotherapy drugs may respond better to some cancer types, although the side effects may be more significant.

Overall, treatment selection should be an individualized decision-making process based on the patient's specific circumstances, pathological characteristics, and treatment goals. Patients work closely with their doctors to choose the treatment options that are best for their condition.

The original drug of sotorasibu has not yet been launched in China, so patients cannot purchase it domestically and need to purchase sotorasibu through overseas channels. The specifications of the original research version of sotorasibu in Hong Kong, China120mg*240tablets are priced at8Around 10,000, the European version of the original drug with the same specifications costs around 4 0,000, which is relatively expensive. The cheaper ones are the generic drugs marketed abroad. For example, the price of generic drugs in Laos and Bangladesh is around two to three thousand yuan. The price is relatively cheap, and the ingredients of foreign generic drugs are basically the same as the original drugs.