What are the precautions for acalabrutinib?

Acalabrutinibis a BTKinhibitor. Acalabrutinib is indicated for the treatment of mantle cell lymphoma in adults who have received at least one previous cancer treatment (MCL), this drug is also used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).

Acalabrutinib(Acalabrutinib)What are the precautions?

1.Serious and opportunistic infections. Fatal and serious infections, including opportunistic infections, have occurred in patients with hematological malignancies receivingacabrutinib. In clinical trials, 19%of 1,029patients exposed to CALQUENCE developed serious or Grade 3 or higher infections(bacteria , viruses or fungi), most commonly due to respiratory infections(11% of all patients, including 6% pneumonia). Consider prophylaxis for patients at increased risk for opportunistic infections, monitor patients for signs and symptoms of infection, and treat promptly.

2.Bleeding. Fatal and serious bleeding events have occurred in patients with hematological malignancies when treated with calciferol. Taking this product with antithrombotic drugs may further increase the risk of bleeding. In clinical trials, major bleeding occurred in 2.7%of patients taking carquelin without an antithrombotic agent and in 3.6%of patients taking carqueline but taking an antithrombotic agent. Consider the risks and benefits of coadministering antithrombotic drugs with Carquis. Monitor patients for signs of bleeding. Depending on the type of surgery and risk of bleeding, consider the pros and cons of stopping medication before and 3 to 7 days after surgery.

3.Cytopenia. Grade 3 or 4 cytopenias, including neutropenia (23%), anemia(8%), thrombocytopenia(7%), and lymphocytopenia(7%) occurred in patients with hematological malignancies receiving carquine. Grade 4 neutropenia occurred in 12% of patients. Monitor complete blood counts regularly during treatment. Interrupt treatment, reduce dose, or discontinue treatment as needed.

4.Second primary malignant tumor. The most common second primary malignancy is skin cancer, which is reported in 6% of patients. Monitor patients with skin cancer and recommend avoiding sun exposure.

5.Atrial fibrillation and flutter. Patients with cardiac risk factors, hypertension, previous cardiac arrhythmias, and acute infections may be at increased risk. Monitor arrhythmia symptoms(such as palpitations, dizziness, syncope, dyspnea)and handle them appropriately.

6.Using this drug during pregnancy can harm the fetus. If the patient is a woman who can become pregnant, the doctor may test to make sure there is no pregnancy before starting this medication. Use effective contraception to prevent pregnancy during treatment and for at least 1 weeks after the last dose. If a patient thinks they are pregnant while taking this medication, contact their doctor immediately.

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