How many boxes of trametinib can I take in a month?

According to clinical guideline information, Trametinib (Trametinib) is generally recommended to be taken orally at 2 mg at the same time each day, at least 1 hour before or 2 hours after a meal on an empty stomach. The recommended dose for pediatric patients weighing 26-37 kg is 1 mg orally once daily, for pediatric patients 38-50 kg the recommended dose is 1.5 mg orally once daily, and for pediatric patients 51 kg or above the recommended dose is 2 mg orally once daily.

Trametinib is available in the form of tablets and oral solutions. Common tablet specifications are0.5mg*30 tablets and 2mg*30 tablets. The oral solution specification contains 4.7mg trametinib per bottle. The recommended treatment duration for patients with trametinib is until disease progression or unacceptable toxicity, but in the adjuvant melanoma setting, the recommended treatment duration is until disease recurrence or unacceptable toxicity reaches 1 year. Taking the specification of 2mg*30 tablets as an example, an adult patient may need to use about one box of trametinib for one month of treatment, provided that the patient does not interrupt, reduce or stop treatment due to other factors.

The original drug of Trametinib has been launched in China and is included in the scope of medical insurance, but it may only be available to patients who meet the indications. The price of 2 mg*30 tablets is more than RMB 10,000. The original drug of Trametinib sold overseas, with the price of 2 mg*30 tablets, is more than RMB 7,000 (the price may fluctuate due to exchange rates). There are also generic trametinib drugs produced in other countries overseas, and their drug ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of a 2mg*30 tablet of a generic drug produced by a Laos pharmaceutical factory is more than 2,000 yuan (the price may fluctuate due to the exchange rate).