Is Imatinib a targeted drug?

Imatinib is a targeted drug that targets several protein tyrosine kinases, Abl, Arg (Ablrelated genes), stem cell factor receptor(c-KIT), platelet-derived growth factor receptor(PDGF-R)and their oncogenic forms, most notably BCR-ABL. Imatinib is indicated for Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+) and acute lymphoblastic leukemia (ALL) >, certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndromes.

Imatinib The most commonly reported adverse reactions (greater than or equal to30%) are edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue and abdominal pain etc. Imatinib is a small molecule kinase inhibitor. Imatinib mesylate film-coated tablets contain imatinib mesylate equivalent to 100 mg or 400 mg imatinib free base. The chemical name of imatinib mesylate is 4-[(4-methyl1-piperazinyl)methyl]-N-[4-methyl -3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]-phenyl]Benzamide methanesulfonate. Imatinib mesylate is an off-white to light yellow crystalline powder. Its molecular formula is C29H31N7O CH4Therefore 3Its molecular weight is 589.7. Imatinib mesylate is soluble in water and slightly soluble in methanol and dimethyl sulfoxide. Inactive Ingredients: Povidone (USP) and Magnesium Stearate (NF). Tablet coating:Hypromellose(USP), iron oxide yellow(NF), polyethylene glycol( NF), talc(USP), titanium dioxide(USP)and iron oxide red(NF). IndiaNATCOPharmaceutical retail price100mg120 tablets is about 400. IndiaCiplaPharmaceutical retail price per box100mg10 capsules40yuan. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.