Is there a difference between Imatinib and Gleevec?

Imatinib (Imatinib)There is no difference between Imatinib and Gleevec. The trade name of Imatinib is Gleevec. Imatinib is an oral targeted therapy used to treat cancer, marketed under the brand names Gleevec and Glivec (both marketed globally by Novartis). Imatinib is a drug targeting CSF1R, ABL, c-KIT Small molecule inhibitors of various tyrosine kinases such as span>, FLT3 and PDGFR-β. Imatinib is indicated for Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+) and acute lymphoblastic leukemia (ALL) >, certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndromes.

Imatinib was approved for medical use in the United States in 2001. A generic version has been available in the UK since2017. ImatinibCommon side effects include vomiting, diarrhea, muscle pain, headache, and rash. Serious side effects may include fluid retention, gastrointestinal bleeding, bone marrow suppression, liver problems, and heart failure. Pregnancy during use may cause harm to the baby. Imatinib works by stopping the Bcr-Abl tyrosine kinase, which may slow the growth or cause programmed cell death in certain types of cancer cells.

Do not use in humansCYP3A4inhibitors such as clarithromycin, chloramphenicol, ketoconazole, ritonavir and nefazodone due to its dependenceCYP3A4For metabolism. Likewise, it is an inhibitor of CYP3A4, CYP2D6 and CYP2C9, therefore concurrent treatment with substrates of these enzymes may increase plasma concentrations of the drugs. Because imatinib is metabolized primarily by the hepatic enzyme CYP3A4, substances that affect the activity of this enzyme can alter the plasma concentration of the drug. An example of a drug that increases imatinib activity by blocking CYP3A4 and thereby increasing side effects is ketoconazole. The same applies to itraconazole, clarithromycin, grapefruit juice, etc. In contrast, CYP3A4 inductors such as rifampicin and St. John's wort reduce the activity of drugs, risking treatment failure. Imatinib can also act as an inhibitor of CYP3A4, 2C9 and 2D6, increasing the plasma concentrations of many other drugs, such as simvastatin, cyclosporine, Pimozide, Warfarin, Metoprolol, and possibly paracetamol. This drug also reduces plasma levothyroxine through an unknown mechanism. As with other immunosuppressants, live vaccines are used because the microorganisms in the vaccine can multiply and infect the patient. Inactive and toxoid vaccines do not have this risk but may be ineffective under imatinib treatment. Eating grapefruit and drinking grapefruit juice is strongly discouraged because it increases the concentration of imatinib in the blood. IndiaNATCOPharmaceutical retail price100mg120 tablets is about 400. IndiaCiplaPharmaceutical retail price per box100mg10 capsules40yuan. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.