What is the mechanism of action of Axitinib?

Axitinib is an anti-tumor drug with the trade name Inlyta. Axitinib is a small molecule tyrosine kinase inhibitor developed by Pfizer. Axitinib is a second-generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).

Axitinib(Axitinib)What is its mechanism of action?

Axitinib has been shown to inhibit receptor tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2 and VEGFR-3 at therapeutic plasma concentrations. These receptors have been implicated in pathological angiogenesis, tumor growth, and cancer progression. In vitro and in mouse models, ataxinib inhibits VEGF-mediated endothelial cell proliferation and survival, and in tumor xenograft mouse models, ataxinib was shown to inhibit tumor growth and phosphorylation of VEGFR-2. Aaxitinib is a white to light yellow powder with a pKa of 4.8. The solubility of axitinib in aqueous media ranging from pH 1.1 to pH 7.8 is more than 0.2 g/mL. The partition coefficient(n-octanol/water) is 3.5. There are generic drugs in Bangladesh. The retail price of Bangladesh Beacon Pharmaceutical is about 1,800 yuan for 5 mg and 60 tablets. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.

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