What are the precautions for taking Axitinib?

Axitinibis a kinase inhibitorAxitinib is an oralVEGFR and kinase inhibitor indicated for the treatment of a type of advanced renal cell carcinoma(RCC) after failure of prior systemic therapy. Axitinib prevents the development of cancer by inhibiting angiogenesis and preventing tumor growth. What are the precautions for taking Axitinib(Axitinib)?

1.Hypertension may occur, hypertension, including hypertensive crisis, has been observed. Blood pressure should be well controlled before starting axitinib. Monitor hypertension and treat as needed,Depending on the severity of hypertension, withhold medication and then immediately reduce dose or permanently discontinue.

2.Arterial and venous thromboembolic events may occur, Arterial and venous thromboembolic events have been observed and may be fatal. Use with caution in patients at increased risk for these events. If an arterial thromboembolic event occurs during treatment, permanently discontinue axitinib. Depending on the severity of VTE, withhold axitinib and then resume the same dose or permanently discontinue.

3.Bleeding and bleeding events, including fatal events, may occur. Axitinib has not been studied in patients with untreated brain metastases or evidence of recent active gastrointestinal bleeding and should not be used in these patients. Depending on the severity and duration of bleeding, withhold the medication and then reduce or discontinue the medication immediately.

4.Heart failure may occur, Heart failure has been observed and may be fatal. Monitor for signs or symptoms of heart failure throughout treatment with axitinib, management of heart failure may require dose reduction, dose interruption, or permanent discontinuation of axitinib.

5.Gastrointestinal perforation and fistula formation, Gastrointestinal perforation and fistula, including death, have occurred. Use with caution in patients at risk for gastrointestinal perforation or fistula.

6.Hypothyroidism,Hypothyroidism requiring thyroid hormone replacement has been reported. Monitor thyroid function before initiatingaxitinibtreatment and periodically throughout treatment.

7.Poor wound healing, discontinue axitinib at least 2 days before elective surgery. Do not administer this medication for at least 2 weeks after major surgery until the wound has completely healed. Depending on the severity and persistence of impaired wound healing, reduce dose or discontinue axitinib. Resume after resolution of wound healing complicationsThe safety of axitinibhas not been established.

8.Reversible posterior leukoencephalopathy syndrome (RPLS), has been observedRPLS. If signs or symptoms of RPLS occur, permanently discontinue axitinib.

9.Proteinuria, Monitor for proteinuria before initiatingaxitinibtherapy and periodically throughout treatment. For moderate to severe proteinuria, the drug should be withheld and the intravenous dose reduced.

10.Hepatotoxicity:Elevated liver enzymes have occurred during treatment withaxitinibas a single agent. MonitorALT, ASTand bilirubin before initiatingaxitinibtreatment and periodically throughout treatment. A higher frequency of 3 may occur when used in combination with avelumab or pembrolizumab grade and 4 grade ALT and AST were elevated.考虑更频繁地监测肝酶。 Discontinue INLYTA and avelumab or pembrolizumab as needed, initiate corticosteroid therapy as needed, and permanently discontinue the combination due to severe or life-threatening hepatotoxicity. There are generic drugs in Bangladesh. The retail price of Bangladesh Beacon Pharmaceutical is about 1,800 yuan for 5 mg and 60 tablets. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to learn more about high-quality overseas drugs for you.