What should you not eat while being treated with bedaquiline?

During treatment with bedaquiline, which is typically taken with food to increase its oral bioavailability, administration with a standard meal containing approximately 22 grams of fat (558 kcal total) increased relative bioavailability approximately 2-fold compared to administration under fasted conditions. Patientsshould avoid the following foods or medications:

1. Grapefruit or grapefruit juice: Ingredients in grapefruit may affect the metabolism of bedaquiline and increase its concentration in the body, thereby increasing the risk of side effects.

2. Alcohol: Drinking alcohol may interact with bedaquiline, increasing the risk of heart problems and liver damage.

3. Drugs with cardiac effects: Use with bedaquiline may increase the risk of heart problems. Before taking bedaquiline, ask your doctor for advice about the use of other medicines.

4. Hepatotoxic drugs: Combination with bedaquiline may increase the risk of liver damage. Before using bedaquiline, tell your doctor about all the drugs you are using.

The drug is marketed in China as bedaquiline fumarate tablets and has been included in the scope of medical insurance. The common specificationsThe price of 100mg*24 tablets per box may be around 10,000 yuan, which is relatively expensive. The Russian version of bedaquiline sold overseas, Specification100mg*188 tablets per box, may cost around RMB 15,000 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of bedaquiline sold domestically and abroad are basically the same, and there are currently no generic bedaquiline drugs on the market. For specific prices and drug information of overseas drugs, please consult Yaode Medical Consultant.