Lorlatinib survival

According to some early studies, lorlatinib has shown significant anti-tumor activity against NSCLC with mutations in the ALK or ROS1 genes. A pivotal clinical trial called the CROWN study found that ALKpositive patients who had not received ALK inhibitor treatment >NSCLCPatients, lorlatinib significantly prolonged progression-free survival (progression-free) compared with standard treatments (platinum chemotherapy drugs and pemetrexed) survival, PFS).

In this clinical trial, patients treated with lorlatinib had a median PFS of 27.5 months, compared with a median PFS of 8.2 months in the control group. This data demonstrates that lorlatinib achieves a significant survival advantage in first-line treatment. In addition, lorlatinib has also shown a relatively good survival effect in the treatment of NSCLC patients with ALK or ROS1 ROS1 gene mutations, especially those who are resistant to other ALK inhibitors.

However, it is important to note that survival data may vary depending on patient population, study design and other factors. Therefore, when evaluating the survival effect of lorlatinib, it is best to refer to the latest and authoritative clinical trial results to obtain more accurate and reliable information. During the treatment process, doctors usually develop a personalized treatment plan based on the patient's specific situation, and closely monitor the patient's disease progression and survival data in order to adjust treatment strategies in a timely manner.

Lorlatinib has been launched in China and is included in medical insurance. Patients can purchase it domestically, but the price is relatively high, about 10,000 to 20,000 yuan. Please consult the local hospital pharmacy for specific medical insurance reimbursement prices. There are original lorlatinib drugs and cheaper generic drugs abroad. The cheaper ones are the original drug from Turkey, which costs more than 1,000 yuan, and the original drug from Hong Kong, China, which costs about 30,000 yuan. Generic drugs are mainly generic drugs from Laos and Bangladesh. The price is about several thousand yuan, and the ingredients of the original drugs and generic drugs are basically the same.