Everolimus side effects and treatments

Everolimus is a MTOR inhibitor, suitable for patients with advanced hormone receptors who have failed treatment with letrozole or anastrozole. Postmenopausal women with body-positive, HER2-negative breast cancer, advanced renal cell carcinoma after failure of sunitinib or sorafenib, and progressive neuroendocrine tumors located in the pancreas (PNET ),These tumors cannot be surgically removed or are metastatic; they are also suitable for well-differentiated, non-functioning neuroendocrine tumors of the gastrointestinal (GI) or lungs(NET), and are suitable for the treatment of patients with tuberous sclerosis (TSC) who do not require immediate surgery. Non-cancerous renal tumor (Renal angiomyolipoma) is suitable for SEGATSC patients who require therapeutic intervention but cannot be radically removed. It is suitable for the prevention of organ rejection in patients with low to moderate immune risk.

1.Lung or breathing problems may occur. In some people, lung or breathing problems can be serious and even lead to death. If you have a cough, shortness of breath, chest pain, difficulty breathing or wheezing, please inform your doctor immediately.

2. May be more susceptible to infections, such as pneumonia, or bacterial, fungal or viral infections. Viral infections may include active hepatitis B (reactivation) in people who have had hepatitis B in the past. In some people, including adults and children, these infections can be serious and may lead to death, and patients may need treatment as soon as possible. If you have a body temperature of 38.0°C or above, have chills, or feel uncomfortable, please inform your doctor immediately.

3. Severe allergic reactions may occur. If you develop signs and symptoms of a serious allergic reaction, including:rash, itching, hives, flushing, difficulty breathing or swallowing, chest pain, or dizziness, contact your doctor immediately.

4.People who take angiotensin-converting enzyme(ACE) inhibitor drugs during treatment with everolimus may have an increased risk of an allergic reaction called angioedema. If you are not sure whether you are taking an ACE inhibitor medication, consult your doctor before taking this medication.. Get medical help right away if you have difficulty breathing or swelling of your tongue, mouth, or throat during treatment with this medication.

5.Oral ulcers and sores. Mouth sores and ulcers are common during treatment with everolimus but can be serious. When starting treatment with one of these medications, your doctor may tell you to start using a prescription mouthwash at the same time to reduce the likelihood and severity of mouth sores or sores. Follow your healthcare provider's instructions for using this prescription mouthwash. Tellyour doctor if you develop pain, discomfort, or mouth sores. Your doctormay recommend that you go back to using this mouthwash, or use a special mouthwash or oral gel that does not contain alcohol, peroxide, iodine, or thyme.

6. Patients may develop kidney failure. For some people, this can be serious and even lead to death. Doctorsshould check kidney function before and during treatment.

If patients experience any of the serious side effects listed above, they may need to stop taking everolimus for a period of time or use a lower dose and follow their doctor 's instructions.

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