What is the mechanism of action of Sorafenib?

Sorafenib is marketed as Nexavar (US) by Bayer and is an anticancer drug approved by the US FDA for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. Sorafenib inhibits tumor growth and angiogenesis by targeting the RAF/MEK/ERK pathway and receptor tyrosine kinases.

Sorafenib is a kinase inhibitor that reduces tumor cell proliferation in vitro. Sorafenib inhibits a variety of intracellular (c-CRAF, BRAF and mutant BRAF) and cell surface kinases (KIT, FLT- 3, RET, RET/PTC, VEGFR-1, VEGFR- 2, VEGFR- 3and PDGFR-1). Several of these kinases are thought to be involved in tumor cell signaling, angiogenesis, and apoptosis. Sorafenib inhibits tumor growth of HCC, RCC, and DTC human tumor xenografts in immunodeficient mice. After sorafenib treatment, reduced tumor angiogenesis was observed in HCC and renal cell carcinoma models, and increased tumor cell apoptosis was observed in HCC, renal cell carcinoma, and DTC models. The mean relative bioavailability after administration of sorafenib tablets compared to oral solution was 38–49%. After oral administration, sorafenib reaches peak plasma concentrations in approximately 3 hours. The mean elimination half-life of sorafenib is approximately 25 to 48 hours. Sorafenib is oxidatively metabolized by the liverCYP3A4 and UGT1A9 undergoes glucuronidation. The retail price of Bangladesh Yaopin International Pharmaceutical 0.2g*120 tablets is about 700 yuan. The retail price of pharmaceuticals in Laos and ASEAN is about 0.2g*56 tablets500yuan. IndiaNATCOPharmaceutical retail price0.2g*120tablets1000yuan. If you want to get more high-quality information, you can contact YaDE. YaDE will do its best to learn more about high-quality overseas drugs for you.