Sorafenib (Sorafenib) effects and efficacy

Sorafenib is an anti-cancer drug, suitable for advanced renal cancer, unresectable hepatocellular carcinoma, and local recurrence or metastasis, progressive, differentiated thyroid cancer that is ineffective in radioactive iodine therapy(DTC). Sorafenib belongs to the kinase inhibitor class of drugs. It works by blocking the activity of an abnormal protein that sends a reproduction signal to cancer cells, which helps prevent the spread of cancer cells.

Sorafenib is a kinase inhibitor that reduces tumor cell proliferation in vitro. Sorafenib inhibits a variety of intracellular (c-CRAF, BRAF and mutated BRAF) and cell surface kinases (KIT, FLT- 3, RET, RET/PTC, VEGFR-1, VEGFR- 2, VEGFR- 3and PDGFR-1). Several of these kinases are thought to be involved in tumor cell signaling, angiogenesis, and apoptosis. Sorafenib inhibits tumor growth of HCC, RCC, and DTC human tumor xenografts in immunodeficient mice. After sorafenib treatment, reduced tumor angiogenesis was observed in HCC and renal cell carcinoma models, and increased tumor cell apoptosis was observed in HCC, renal cell carcinoma, and DTC models.

Effects of strong CYP3A4 inhibitors on sorafenib: Ketoconazole is a strong inhibitor of CYP3A4 and P- glycoproteins and does not alter a single oral administration of 50 in healthy subjects at doses of 400 mgAverageAUC of Nesava. CYP3A4Effects of strong inducers on sorafenib:In healthy volunteers, rifampicin was administered at a dose of 600 mg once daily for 5 days versus a single oral dose of 400 mgThe coadministration of NEXAVAR resulted in a average AUC decrease of 37% of sorafenib. The retail price of Bangladesh Yaopin International Pharmaceutical 0.2g*120 tablets is about 700 yuan. The retail price of pharmaceuticals in Laos and ASEAN is about 0.2g*56 tablets500yuan. IndiaNATCOPharmaceutical retail price0.2g*120tablets1000yuan. If you want to get more high-quality information, you can contact YaoDE. YaoDE will do its best to help you learn more about overseas high-quality drugs